Article
RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma.
Science advances - 1 Jul 2020
Jiao Fangfang, Li Ze, He Chen, Xu Wenqi, Yang Gensheng, Liu Tingting, Shen Hongjie, Cai Jiajun, Anastas Jamie N, Mao Ying, Yu Yongchun, Lan Fei, Shi Yujiang Geno, Jones Chris, Xu Yanhui, Baker Suzanne J, Shi Yang, Guo Rui
Abstract excerpt
Histone H3 point mutations have been identified in incurable pediatric brain cancers, but the mechanisms through which these mutations drive tumorigenesis are incompletely understood. Here, we provide evidence that RACK7 (ZMYND8) recognizes the histone H3.3 patient mutation (H3.3G34R) in vitro and in vivo. We show that RACK7 binding to H3.3G34R suppresses transcription of CIITA, which is the master regulator of...
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