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FBLN7 mediates vascular smooth muscle cell phenotype switching and vascular remodeling in hypertension.

Theranostics - 1 Jan 2024

Yao Guoqing, Zheng Xuehui, Hu Yang, Zhao Yuan, Kong Binghui, Ti Yun, Bu Pei Li

Abstract excerpt

Rationale: Arterial remodeling serves as a pivotal mechanism underlying the development of diseases such as hypertension. Fibulin-7 (FBLN7), an adhesion protein, remains enigmatic regarding its role in these pathological processes. This study aims to explore whether FBLN7 influences vascular remodeling and its underlying mechanisms. Methods: We generated FBLN7 knockout mice and smooth muscle-specific FBLN7...

Topics

Animals
Vascular Remodeling
Muscle, Smooth, Vascular
Mice
Mice, Knockout
Hypertension
Angiotensin II
Myocytes, Smooth Muscle
Phenotype
Male
Syndecan-4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Models, Animal

Trans-Activators

Mice, Inbred C57BL

Calcium-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39659565
DOI: 10.7150/thno.102593
PMCID: PMC11626941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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