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Article

HSPB7 Deficiency Drives Aortic Aneurysm Progression in Marfan Syndrome Through Vascular Smooth Muscle Cell Phenotypic Switching.

Clinical and experimental pharmacology & physiology - 1 Jun 2026

An Zining, Yan Tao, Ming Yang, Tang Zhiwei, Yang Zhaohua, Zhang Hui, Zhu Kai, Shao Yongfeng

Abstract excerpt

Marfan syndrome (Mfs) arises from mutations in FBN1, predisposing individuals to thoracic aortic aneurysm (TAA) through abnormal smooth muscle cell behaviour. The role of HSPB7 in Mfs-related TAA remains poorly understood. By integrating multi-omics analysis with hiPSC-derived VSMCs from patients with Mfs, we elucidated the molecular landscape of Mfs-associated TAA. Analysis revealed immune cell infiltration, a...

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Share to Aortic Aneurysm, Thoracic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HSP27 Heat-Shock Proteins

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Share to Muscle, Smooth, Vascular

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Source

Identifiers

PMID: 42203489
DOI: 10.1111/1440-1681.70128

Genes

HSPB7
FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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