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Article

Modulating vascular smooth muscle cell phenotype via Wnt-Independent FRZB pathways.

Archives of biochemistry and biophysics - 1 Feb 2025

Kim Hyomin, Kim Eun Kyoung, Yu Yeuni, Heo Hye Jin, Kim Dokyoung, Cho Su-Yeon, Kwon Yujin, Kim Won Kyu, Kim Kihun, Ko Dai Sik, Kim Yun Hak

Abstract excerpt

BACKGROUND AND AIMS: Vascular smooth muscle cells are pivotal in atherosclerosis, transitioning from a contractile to a synthetic phenotype, which is associated with increased proliferation and inflammation. FRZB, a Wnt signaling modulator, has been implicated in vascular pathology, but its specific role in vascular smooth muscle cell phenotype modulation is not well understood. This study investigates the role...

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Atherosclerosis
Cell Movement
Cell Proliferation
Gene Knockdown Techniques
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

Wnt Signaling Pathway

Source

Identifiers

PMID: 39778670
DOI: 10.1016/j.abb.2025.110290

Genes

FRZB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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