Article
Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2010
Barnes Ralston M, Firulli Beth A, Conway Simon J, Vincentz Joshua W, Firulli Anthony B
Abstract excerpt
The basic Helix-Loop-Helix (bHLH) transcription factors Hand1 and Hand2 play critical roles in the development of multiple organ systems during embryogenesis. The dynamic expression patterns of these two factors within developing tissues obfuscate their respective unique and redundant organogenic functions. To define cell lineages potentially dependent upon Hand gene expression, we generated a mutant allele in...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cardiovascular System
- Embryo, Mammalian
- Female
- Genotype
- Immunohistochemistry
- In Situ Hybridization
- Male
- Mesoderm
- Mice
- Mice, Knockout
- Neural Crest