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Article

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2010

Firulli Beth A, McConville David P, Byers James S, Vincentz Joshua W, Barnes Ralston M, Firulli Anthony B

Abstract excerpt

Loss-of-function analysis of the basic helix-loop-helix (bHLH) transcription factor Hand1 indicates critical roles in development. In an effort to generate a Hand1 cDNA knock-in reporter mouse, we generated two hypomorphic alleles, which extend embryonic survival to between embryonic day (E) 10.5...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Immunohistochemistry

Share to In Situ Nick-End Labeling

Share to Mice, Knockout

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

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Identifiers

PMID: 20737509
DOI: 10.1002/dvdy.22402
PMCID: PMC2967597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20737509-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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