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Article

DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis.

Development (Cambridge, England) - 1 Mar 2009

Liu Ning, Barbosa Ana C, Chapman Shelby L, Bezprozvannaya Svetlana, Qi Xiaoxia, Richardson James A, Yanagisawa Hiromi, Olson Eric N

Abstract excerpt

The basic helix-loop-helix (bHLH) transcription factor Hand2 is required for growth and development of the heart, branchial arches and limb buds. To determine whether DNA binding is required for Hand2 to regulate the growth and development of these different embryonic tissues, we generated mutant mice in which the Hand2 locus was modified by a mutation (referred to as Hand2(EDE)) that abolished the DNA-binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19211672
DOI: 10.1242/dev.034025
PMCID: PMC2727559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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