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Article

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field Development

14 Nov 2008

Abstract excerpt

The cardiac neural crest (cNC) lineage plays key roles in heart development by directly contributing to heart structures and regulating development of other heart lineages. The basic helix-loop-helix factor Hand2 regulates development of cardiovascular structures and NC-derived tissues including those that contribute to face and peripheral nervous system. Although Hand2 is expressed in cNC, its role has not been...

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PMID: 19008477
DOI: 10.1161/circresaha.108.180083

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