Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.

doi:10.1038/s41588-024-01999-x

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Article

Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.

Nature genetics - 1 Dec 2024

Leppä Aino-Maija, Grimes Karen, Jeong Hyobin, Huang Frank Y, Andrades Alvaro, Waclawiczek Alexander, Boch Tobias, Jauch Anna, Renders Simon, Stelmach Patrick, Müller-Tidow Carsten, Karpova Darja, Sohn Markus, Grünschläger Florian, Hasenfeld Patrick, Benito Garagorri Eva, Thiel Vera, Dolnik Anna, Rodriguez-Martin Bernardo, Bullinger Lars, Mrózek Krzysztof, Eisfeld Ann-Kathrin, Krämer Alwin, Sanders Ashley D, Korbel Jan O, Trumpp Andreas

Abstract excerpt

Chromosomal instability is a major driver of intratumoral heterogeneity (ITH), promoting tumor progression. In the present study, we combined structural variant discovery and nucleosome occupancy profiling with transcriptomic and immunophenotypic changes in single cells to study ITH in complex karyotype acute myeloid leukemia (CK-AML). We observed complex structural variant landscapes within individual cells of...

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PMID: 39587361
DOI: 10.1038/s41588-024-01999-x
PMCID: PMC11631769

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