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Article

AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology.

Blood advances - 14 Nov 2023

Klever Marius-Konstantin, Sträng Eric, Hetzel Sara, Jungnitsch Julius, Dolnik Anna, Schöpflin Robert, Schrezenmeier Jens-Florian, Schick Felix, Blau Olga, Westermann Jörg, Rücker Frank G, Xia Zuyao, Döhner Konstanze, Schrezenmeier Hubert, Spielmann Malte, Meissner Alexander, Melo Uirá Souto, Mundlos Stefan, Bullinger Lars

Abstract excerpt

Acute myeloid leukemia with complex karyotype (CK-AML) is associated with poor prognosis, which is only in part explained by underlying TP53 mutations. Especially in the presence of complex chromosomal rearrangements, such as chromothripsis, the outcome of CK-AML is dismal. However, this degree of complexity of genomic rearrangements contributes to the leukemogenic phenotype and treatment resistance of CK-AML...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37582288
DOI: 10.1182/bloodadvances.2023010887
PMCID: PMC10632680

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