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An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells

21 Nov 2024

Abstract excerpt

EpCAM and its close relative Trop2 are well-known cell surface markers of carcinoma, but their potential role in cancer metastasis remains unclear. They are known, however, to downregulate myosin-dependent contractility, a key parameter involved in adhesion and migration. We investigate here the morphogenetic impact of the high EpCAM and Trop2 levels typically found in epithelial breast cancer cells, using...

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PMID: 39572744
DOI: 10.1038/s44318-024-00309-9

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