Article

YAP localization mediates mechanical adaptation of human cancer cells during extravasation <i>in vivo</i>

2023-11-16

Abstract excerpt

Biophysical profiling of primary tumors has revealed that individual tumor cells fall along a highly heterogeneous continuum of mechanical phenotypes. One idea is that a subset of tumor cells is “softer” to facilitate detachment and escape from the primary site, a step required to initiate metastasis. However, it has also been postulated that cells must be able to deform and generate sufficient force to exit into...

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Identifiers and source

Literature Corpus work: 61785950-feb3-5f0c-be21-94f822e11b74
DOI: 10.1101/2023.11.14.567015

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