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Article

YAP-independent mechanotransduction drives breast cancer progression

23 Apr 2019

Abstract excerpt

Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, the role of YAP during in vivo breast cancer remains unclear. Here, we find that mechanotransduction occurs independently of YAP in breast cancer patient samples and mechanically tunable 3D cultures. Mechanistically, the...

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PMID: 31015465
DOI: 10.1038/s41467-019-09755-0

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