Article
SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2015
McGrail Daniel J, Mezencev Roman, Kieu Quang Minh N, McDonald John F, Dawson Michelle R
Abstract excerpt
A growing body of evidence suggests that the developmental process of epithelial-to-mesenchymal transition (EMT) is co-opted by cancer cells to metastasize to distant sites. This transition is associated with morphologic elongation and loss of cell-cell adhesions, though little is known about how it alters cell biophysical properties critical for migration. Here, we use multiple-particle tracking (MPT)...
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