Article

Deciphering the Mechanotransduction Symphony: Stiffness-Dependent Interplay of YAP and β-Catenin in Breast Cancer Metastasis

2024-03-10

Abstract excerpt

Metastatic breast cancer poses a formidable clinical challenge, demanding a comprehensive understanding of the intricate signaling networks orchestrating disease progression. Herein, our findings revealed a pronounced increase in the nuclear translocation of both YAP and β-catenin in MDA-MB-231 cells exposed to a stiff substrate (32 kPa). Intriguingly, YAP knockdown resulted in elevated β-catenin nuclear transloca...

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Literature Corpus work: e3cf80e8-8e5a-56c0-8152-e2b411d9d6ef
DOI: 10.22541/au.171008008.88635673/v1

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