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An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells

2022-10-04

Abstract excerpt

EpCAM and its close relative Trop2 are well-known markers of carcinoma, but the potential role of these cell surface proteins in cancer metastasis remains unclear. They are known, however, to downregulate myosin-dependent contractility, a key parameter involved in cell adhesion and migration. We investigate here the morphogenetic impact of the high EpCAM and Trop2 levels typically found in epithelial breast cancer...

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Literature Corpus work
2e9ecb11-91ac-5bda-a5a0-5faf5da480a0
DOI
10.1101/2022.10.03.510449
Open publication

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An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cellsDOI 10.1101/2022.10.03.510449
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