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Article

Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2020

Leggett Susan E, Patel Mohak, Valentin Thomas M, Gamboa Lena, Khoo Amanda S, Williams Evelyn Kendall, Franck Christian, Wong Ian Y

Abstract excerpt

Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidate collective dissemination during disease progression and enable preclinical testing of targeted antimigration therapies. However, past 3D traction measurements have...

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Identifiers

PMID: 32123100
DOI: 10.1073/pnas.1918296117
PMCID: PMC7084145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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