Article
Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder.
The Lancet. Respiratory medicine - 1 May 2022
Cho Michael H, Hobbs Brian D, Silverman Edwin K
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease. Susceptibility to and heterogeneity of COPD are incompletely explained by environmental factors such as cigarette smoking. Family-based and population-based studies have shown that a substantial proportion of COPD risk is related to genetic variation. Genetic association studies have identified hundreds of genetic variants that...
Topics
- Cigarette Smoking
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Lung
- Phenotype
- Pulmonary Disease, Chronic Obstructive