Article

Relative Contributions of Family History and a Polygenic Risk Score on COPD and Related Outcomes: COPDGene and ECLIPSE studies

2020-07-24

Abstract excerpt

<h4>Introduction</h4> Family history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (polygenic risk score, or PRS). Whether the PRS and family history provide complementary or redundant information for predicting COPD and related outcomes is unknown. <h4>Methods</h4> We assessed the predictive capacity of family history...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0e0b775-67f9-5388-bea6-4817b4e56e9d
DOI: 10.1101/2020.07.23.20160739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Relative Contributions of Family History and a Polygenic Risk Score on COPD and Related Outcomes: COPDGene and ECLIPSE studiesDOI 10.1101/2020.07.23.20160739Read

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.Semantic proximity Read

Family history is a risk factor for COPD.Semantic proximity Read

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable ProteinsSemantic proximity Read

Associations of genetic risk and smoking with incident COPDSemantic proximity Read

A polygenic risk score and age of diagnosis of COPD.Semantic proximity Read

Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviorsSemantic proximity Read

Smoking Interaction with a Polygenic Risk Score for Reduced Lung FunctionSemantic proximity Read

Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder.Semantic proximity Read

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.Semantic proximity Read

Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk predictionSemantic proximity Read

Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score studySemantic proximity Read

Genetics of COPD.Semantic proximity Read