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Article

A polygenic risk score and age of diagnosis of COPD.

The European respiratory journal - 1 Sept 2022

Zhang Jingzhou, Xu Hanfei, Qiao Dandi, DeMeo Dawn L, Silverman Edwin K, O'Connor George T, Hobbs Brian D, Dupuis Josée, Cho Michael H, Moll Matthew

Abstract excerpt

BACKGROUND: Genetic susceptibility may be associated with earlier onset of chronic obstructive pulmonary disease (COPD). We hypothesised that a polygenic risk score (PRS) for COPD would be associated with earlier age of diagnosis of COPD. METHODS: In 6647 non-Hispanic White (NHW) and 2464 African American (AA) participants from COPDGene, and 6812 participants from the Framingham Heart Study (FHS), we tested the...

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Identifiers

PMID: 35115341
DOI: 10.1183/13993003.01954-2021
PMCID: PMC9969342

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