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Article

Memory Phenotype Tfh Cells Develop Without Overt Infection and Support Germinal Center Formation and B Cell Responses to Viral Infection.

European journal of immunology - 1 Jan 2025

Symonds Alistair L J, Busharat Zabreen, Du Mengmeng, Miao Tizong, Li Suling, Hou Xiujuan, Wang Ping

Abstract excerpt

Pathogen-induced memory Tfh cells are important to maintain high-affinity antibodies against pathogens. We have now discovered Tfh cells with a similar memory phenotype (MP) that develop in pathogen-free conditions. These MP Tfh cells are similar to pathogen-induced memory Tfh in both phenotype and function. They express FR4 and Egr2, which are both found in pathogen-induced memory Tfh cells. FR4+Egr2+ CD4 MP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39568245
DOI: 10.1002/eji.202451291
PMCID: PMC11739680

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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