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Article

A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses.

The Journal of experimental medicine - 1 Jan 2024

Feng Han, Zhao Zixuan, Zhao Xiaohong, Bai Xue, Fu Weiwei, Zheng Liangtao, Kang Boxi, Wang Xiaohu, Zhang Zemin, Dong Chen

Abstract excerpt

T follicular helper (Tfh) cells, essential for germinal center reactions, are not identical, with different phenotypes reported. Whether, when, and how they generate memory cells is still poorly understood. Here, through single-cell RNA-sequencing analysis of CXCR5+Bcl6+ Tfh cells generated under different conditions, we discovered, in addition to PD-1hi effector Tfh cells, a CD62L+PD1low subpopulation....

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Identifiers

PMID: 38047912
DOI: 10.1084/jem.20221927
PMCID: PMC10695277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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