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Article

Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis.

Experimental & molecular medicine - 1 May 2023

Cho Min-Ji, Lee Hong-Gyun, Yoon Jae-Won, Kim Gil-Ran, Koo Ja-Hyun, Taneja Reshma, Edelson Brian T, Lee You Jeong, Choi Je-Min

Abstract excerpt

Memory-phenotype (MP) CD4+ T cells are a substantial population of conventional T cells that exist in steady-state mice, yet their immunological roles in autoimmune disease remain unclear. In this work, we unveil a unique phenotype of MP CD4+ T cells determined by analyzing single-cell transcriptomic data and T cell receptor (TCR) repertoires. We found that steady-state MP CD4+ T cells in the spleen were composed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Granulocyte-Macrophage Colony-Stimulating Factor

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 37121980
DOI: 10.1038/s12276-023-00995-1
PMCID: PMC10238403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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