Article

UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis

2025-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Neurological conditions are the leading cause of ill health worldwide. Here, we show that the neurodevelopmental disorder-associated ubiquitin ligase UBE3C regulates the cellular composition of the murine cerebral cortex and human brain organoids, with its loss favoring neurogenesis and suppressing glial fate. Using genetic complementation, we demonstrate that disease-associated UBE3C mutations...

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Literature Corpus work: 4fc20a03-56b5-573b-be4d-f55e151950e9
DOI: 10.1101/2025.04.09.646620

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