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Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Fang Dong, Wang Heping, Zhang Zhiguo

Abstract excerpt

Recently, frequent somatic mutations at histone genes have been detected in high grade pediatric brain tumor, chondroblastoma, and giant cell tumor of bone. These mutant histones are also termed oncohistones. Since oncohistone proteins co-exist with wild type histone proteins in cells, it is critically important to understand how they promote tumorigenesis. Here, we describe two methods to analyze the impact of...

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PMID: 30073537
DOI: 10.1007/978-1-4939-8663-7_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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