ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

doi:10.1016/j.molcel.2016.03.030

Article

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

Molecular cell - 19 May 2016

Atanassov Boyko S, Mohan Ryan D, Lan Xianjiang, Kuang Xianghong, Lu Yue, Lin Kevin, McIvor Elizabeth, Li Wenqian, Zhang Ying, Florens Laurence, Byrum Stephanie D, Mackintosh Samuel G, Calhoun-Davis Tammy, Koutelou Evangelia, Wang Li, Tang Dean G, Tackett Alan J, Washburn Michael P, Workman Jerry L, Dent Sharon Y R

Abstract excerpt

Histone H2B monoubiquitination (H2Bub1) is centrally involved in gene regulation. The deubiquitination module (DUBm) of the SAGA complex is a major regulator of global H2Bub1 levels, and components of this DUBm are linked to both neurodegenerative diseases and cancer. Unexpectedly, we find that ablation of USP22, the enzymatic center of the DUBm, leads to a reduction, rather than an increase, in global H2bub1...

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ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

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