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Article

Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2024

Chong Joanna Su Xian, Ji Fang, Hilal Saima, Chong Joyce Ruifen, Lau Jia Ming, Tong Nathanael Ren Jie, Tan Boon Yeow, Venketasubramanian Narayanaswamy, Lai Mitchell Kim Peng, Chen Christopher Li-Hsian, Zhou Juan Helen

Abstract excerpt

INTRODUCTION: We investigated the effects of multiple cerebrovascular disease (CeVD) neuroimaging markers on brain functional connectivity (FC), and how such CeVD-related FC changes interact with plasma phosphorylated tau (p-tau)181 (an Alzheimer's disease [AD] marker) to influence downstream neurodegeneration and cognitive changes. METHODS: Multivariate associations among four CeVD markers and whole-brain FC in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39537356
DOI: 10.1002/alz.14328
PMCID: PMC11667494

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