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Article

The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity.

CNS neuroscience & therapeutics - 1 Jan 2024

Zhu Yao, Wu Yan, Lv Xinyi, Wu Jiaonan, Shen Chunzi, Tang Qiqiang, Wang Guoping

Abstract excerpt

AIMS: To investigate whether insula network connectivity modulates the relationship between apolipoprotein E (APOE) ε4 genotype, cerebrospinal fluid (CSF) biomarkers (Aβ, Tau, and pTau) and cognition across Alzheimer's disease (AD) spectrum. METHODS: Forty-six cognitive normal (CN), 35 subjective memory complaint (SMC), 41 mild cognitive impairment (MCI), and 32 AD subjects from the Alzheimer's Disease...

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Identifiers

PMID: 37577852
DOI: 10.1111/cns.14401
PMCID: PMC10805399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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