Back to search

Article

Identification of abnormal lipid profiles promote cognitive decline in Alzheimer’s disease spectrum via large-scale brain connectivity

2021-05-13

Abstract excerpt

<h4>Background: </h4> Lipid metabolite dysfunction makes a substantial contribution to the clinical signs and pathophysiology of Alzheimer’s disease (AD). It is unclear that the role of dyslipidemia in the promotion of neuropathological processes and brain functional impairment that subsequently facilitates the progression of AD. <h4>Methods: </h4>: Lipid pathway-based polygenic scores and large-scale resting-stat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a7db64ed-2067-53a7-80d3-8a2b81356f34
DOI
10.21203/rs.3.rs-496187/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of abnormal lipid profiles promote cognitive decline in Alzheimer’s disease spectrum via large-scale brain connectivityDOI 10.21203/rs.3.rs-496187/v1
Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomesSemantic proximity
Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer's disease.Semantic proximity
Multiscale networks in Alzheimer’s disease identify brain hypometabolism as central across biological scalesSemantic proximity
A phenome-wide hunt for risk factors of Alzheimer's disease: from metabolic clues to neuroimaging evidence.Semantic proximity
Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Semantic proximity
Integrative-omics for discovery of network-level disease biomarkers: a case study in Alzheimer's disease.Semantic proximity
Vulnerable Brain Networks Associated with Risk for Alzheimer’s DiseaseSemantic proximity
A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.Semantic proximity
Multiscale Metabolic Covariance Networks Uncover Stage-Specific Biomarker Signatures Across the Alzheimer’s Disease ContinuumSemantic proximity
Additive effects of cerebrovascular disease functional connectome phenotype and plasma p-tau181 on longitudinal neurodegeneration and cognitive outcomes.Semantic proximity
APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity
Alzheimer's disease polygenic risk's association with all-cause dementia through the plasma metabolome in the UK Biobank study.Semantic proximity
Select a neighboring publication to make it the new centre.