Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals.

doi:10.1002/alz.14096

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Article

Alzheimer's disease genetic pathways impact cerebrospinal fluid biomarkers and imaging endophenotypes in non-demented individuals.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2024

Lorenzini Luigi, Collij Lyduine E, Tesi Niccoló, Vilor-Tejedor Natàlia, Ingala Silvia, Blennow Kaj, Foley Christopher, Frisoni Giovanni B, Haller Sven, Holstege Henne, van der van der Lee Sven, Martinez-Lage Pablo, Marioni Riccardo E, McCartney Daniel L, O' Brien John, Oliveira Tiago Gil, Payoux Pierre, Reinders Marcel, Ritchie Craig, Scheltens Philip, Schwarz Adam J, Sudre Carole H, Waldman Adam D, Wolz Robin, Chatelat Gael, Ewers Michael, Wink Alle Meije, Mutsaerts Henk J M M, Gispert Juan Domingo, Visser Pieter Jelle, Tijms Betty M, Altmann Andre, Barkhof Frederik

Abstract excerpt

INTRODUCTION: Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. METHODS: We computed pathway-specific genetic risk scores (GRSs) in non-demented individuals and investigated how AD risk variants predict cerebrospinal fluid (CSF) and imaging biomarkers reflecting...

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PMID: 39073684
DOI: 10.1002/alz.14096
PMCID: PMC11497686

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