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Article

Atlas of human brain imaging-derived phenotypes and disease risk.

Med (New York, N.Y.) - 10 Jul 2026

Liu Qidong, Guo Junrong, Yan Jinfeng, Yu Siqi, Hu Yixin, Deng Yu, Yan Benhuang, Li Ping, Cai Jiajing, Deng Zhenghao, Wang Zixuan, Yu Jian

Abstract excerpt

BACKGROUND: The brain plays a central role in coordinating physiological processes across organ systems, yet population-scale evidence linking brain structure and function alterations, as captured by neuroimaging, to multisystem disease risk remains limited. METHODS: Leveraging multimodal magnetic resonance imaging (MRI) and linked health records from 64,836 participants, we performed a phenome-wide association...

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PMID: 42309062
DOI: 10.1016/j.medj.2026.101185

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