Article

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

2022-06-30

Abstract excerpt

Several bat species act as asymptomatic reservoirs for many viruses that are instead highly pathogenic in other mammals. Here, we have characterized the functional diversification of the Protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive selection and has undergone repeated genomic duplications in bats, in contrast to all studied mammals that poss...

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Literature Corpus work: 802ddb9d-b268-5f3e-859a-a02c9f8ec5f1
DOI: 10.1101/2022.06.28.497829

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