Article
KDM2A and KDM2B protect a subset of CpG islands from DNA methylation.
Journal of genetics and genomics = Yi chuan xue bao - 1 Jan 2025
Liu Yuan, Liu Ying, Zhu Yunji, Hu Di, Nie Hu, Xie Yali, Sun Rongrong, He Jin, Zhang Honglian, Lu Falong
Abstract excerpt
In the mammalian genome, most CpGs are methylated. However, CpGs within the CpG islands (CGIs) are largely unmethylated, which are important for gene expression regulation. The mechanism underlying the low methylation levels at CGIs remains largely elusive. KDM2 proteins (KDM2A and KDM2B) are H3K36me2 demethylases known to bind specifically at CGIs. Here, we report that depletion of each or both KDM2 proteins, or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.