Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the role of mutations in the KMT 2D histone lysine methyltransferase in bladder cancer

4 Feb 2019

Abstract excerpt

Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation of these enzymes affects gene expression, which may lead to tumorigenesis. Here, we performed an integrated analysis of 50 HMTs in bladder cancer and found intrinsic links between copy number alterations, mutations, gene expression levels, and clinical outcomes. Through integrative analysis, we identified six HMT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30984543
DOI: 10.1002/2211-5463.12600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the role of mutations in the KMT 2D histone lysine methyltransferase in bladder cancerPMID 30984543Read ↗

Histone H3 lysine 4 methyltransferase KMT2D.Semantic proximity Read ↗

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.Semantic proximity Read ↗

Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human CancerSemantic proximity Read ↗

The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancerSemantic proximity Read ↗

A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in CancerSemantic proximity Read ↗

Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.Semantic proximity Read ↗

Molecular pathology of urothelial carcinoma.Semantic proximity Read ↗

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.Semantic proximity Read ↗

The role of KMT2 gene in human tumors.Semantic proximity Read ↗

Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate CancerSemantic proximity Read ↗

Y-Linked Lysine(K) Demethylase 5D as a regulator of sex-specific bladder cancer metastasis and prognosisSemantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.