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Article

Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.

Nature communications - 24 Jun 2020

Yagi Masaki, Kabata Mio, Tanaka Akito, Ukai Tomoyo, Ohta Sho, Nakabayashi Kazuhiko, Shimizu Masahito, Hata Kenichiro, Meissner Alexander, Yamamoto Takuya, Yamada Yasuhiro

Abstract excerpt

De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b. We identify 355 and 333 uniquely unmethylated genes in Dnmt3a and Dnmt3b knockout (KO) 2i-MEFs, respectively. We find that Dnmt3a is exclusively required for de novo...

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Identifiers

PMID: 32581223
DOI: 10.1038/s41467-020-16989-w
PMCID: PMC7314859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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