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The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer

21 Jan 2019

Abstract excerpt

Genome-wide studies in tumor cells have indicated that chromatin-modifying proteins are commonly mutated in human cancers. The lysine-specific methyltransferase 2C (KMT2C/MLL3) is a putative tumor suppressor in several epithelia and in myeloid cells. Here, we show that downregulation of KMT2C in bladder cancer cells leads to extensive changes in the epigenetic status and the expression of DNA damage response and...

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PMID: 30665945
DOI: 10.15252/embr.201846821

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