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Article

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

Cell - 5 May 2006

Whetstine Johnathan R, Nottke Amanda, Lan Fei, Huarte Maite, Smolikov Sarit, Chen Zhongzhou, Spooner Eric, Li En, Zhang Gongyi, Colaiacovo Monica, Shi Yang

Abstract excerpt

Histone methylation regulates chromatin structure, transcription, and epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases such as LSD1 and JHDM1, which mediate demethylation of di- and monomethylated histones. It has been unclear whether demethylases exist that reverse lysine trimethylation. We show the JmjC domain-containing protein JMJD2A reversed...

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PMID: 16603238
DOI: 10.1016/j.cell.2006.03.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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