Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

doi:10.1016/j.cell.2006.03.028

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Article

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

Cell - 5 May 2006

Whetstine Johnathan R, Nottke Amanda, Lan Fei, Huarte Maite, Smolikov Sarit, Chen Zhongzhou, Spooner Eric, Li En, Zhang Gongyi, Colaiacovo Monica, Shi Yang

Abstract excerpt

Histone methylation regulates chromatin structure, transcription, and epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases such as LSD1 and JHDM1, which mediate demethylation of di- and monomethylated histones. It has been unclear wheth...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Catalytic Domain
Cell Differentiation
Chromosomes
DNA Methylation
DNA-Binding Proteins
Down-Regulation
Germ Cells
HeLa Cells
Histones
Humans
Jumonji Domain-Containing Histone Demethylases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lysine

Meiosis

Mutation

Oxidoreductases, N-Demethylating

Source

Open in PubMed

Identifiers

PMID: 16603238
DOI: 10.1016/j.cell.2006.03.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-16603238-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.