Article
Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation.
EMBO reports - 1 Dec 2010
Deleris Angelique, Greenberg Maxim V C, Ausin Israel, Law Rona W Y, Moissiard Guillaume, Schubert Daniel, Jacobsen Steven E
Abstract excerpt
Histone demethylases-both lysine-specific demethylase 1 (LSD1) and Jumonji-C (JmjC) domain-containing proteins-are broadly implicated in the regulation of chromatin-dependent processes. In Arabidopsis thaliana, histone marks directly affect DNA methylation, and mutations in LSD1 homologues show reduced DNA methylation at some loci. We screened transfer DNA mutations in genes encoding JmjC domains for defects in...
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