Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.

Cold Spring Harbor perspectives in medicine - 1 May 2017

Fahey Catherine C, Davis Ian J

Abstract excerpt

The H3 lysine 36 histone methyltransferase SETD2 is mutated across a range of human cancers. Although other enzymes can mediate mono- and dimethylation, SETD2 is the exclusive trimethylase. SETD2 associates with the phosphorylated carboxy-terminal domain of RNA polymerase and modifies histones at actively transcribed genes. The functions associated with SETD2 are mediated through multiple effector proteins that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to DNA Repair
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Protein Processing, Post-Translational

Share to RNA Splicing

Share to Transcription Factors

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 28159833
DOI: 10.1101/cshperspect.a026468
PMCID: PMC5411680

Genes

SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.PMID 28159833Read ↗

SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer.Semantic proximity Read ↗

SETD2: an epigenetic modifier with tumor suppressor functionality.Semantic proximity Read ↗

Roles of SETD2 in Leukemia—Transcription, DNA-Damage, and BeyondSemantic proximity Read ↗

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.Semantic proximity Read ↗

Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapySemantic proximity Read ↗

[Research progress on the expression and carcinogenic mechanisms of SETD2 in malignant tumors].Semantic proximity Read ↗

Histone H3 lysine 4 methyltransferase KMT2D.Semantic proximity Read ↗

Identification of functional cooperative mutations of SETD2 in human acute leukemia.Semantic proximity Read ↗

Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation.Semantic proximity Read ↗

SETD2 maintains nuclear lamina stability to safeguard the genomeSemantic proximity Read ↗

Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.Semantic proximity Read ↗

The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.