Article
SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.
Cold Spring Harbor perspectives in medicine - 1 May 2017
Fahey Catherine C, Davis Ian J
Abstract excerpt
The H3 lysine 36 histone methyltransferase SETD2 is mutated across a range of human cancers. Although other enzymes can mediate mono- and dimethylation, SETD2 is the exclusive trimethylase. SETD2 associates with the phosphorylated carboxy-terminal domain of RNA polymerase and modifies histones at...
Topics
- DNA Methylation
- DNA Repair
- Histone-Lysine N-Methyltransferase
- Histones
- Humans
- Mutation
- Neoplasms
- Protein Processing, Post-Translational
- RNA Splicing
- Transcription Factors
- Transcriptional Activation