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Article

Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals.

Nature human behaviour - 1 Feb 2025

Wu Xin-Rui, Li Ze-Yu, Yang Liu, Liu Ying, Fei Chen-Jie, Deng Yue-Ting, Liu Wei-Shi, Wu Bang-Sheng, Dong Qiang, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai

Abstract excerpt

Existing genetic studies of neuroticism have been largely limited to common variants. Here we performed a large-scale exome analysis of white British individuals from UK Biobank, revealing the role of coding variants in neuroticism. For rare variants, collapsing analysis uncovered 14 neuroticism-associated genes. Among these, 12 (PTPRE, BCL10, TRIM32, ANKRD12, ADGRB2, MON2, HIF1A, ITGB2, STK39, CAPNS2, OGFOD1 and...

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Identifiers

PMID: 39511343
DOI: 10.1038/s41562-024-02045-w

Genes

ADGRB2
BCL10
CAPNS2
HIF1A
ITGB2
KDM4B
MADD
MON2
OGFOD1
PTPRE
STK39
TRIM32
TRPC4AP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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