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Article

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.

Molecular psychiatry - 1 Jun 2016

Smith D J, Escott-Price V, Davies G, Bailey M E S, Colodro-Conde L, Ward J, Vedernikov A, Marioni R, Cullen B, Lyall D, Hagenaars S P, Liewald D C M, Luciano M, Gale C R, Ritchie S J, Hayward C, Nicholl B, Bulik-Sullivan B, Adams M, Couvy-Duchesne B, Graham N, Mackay D, Evans J, Smith B H, Porteous D J, Medland S E, Martin N G, Holmans P, McIntosh A M, Pell J P, Deary I J, O'Donovan M C

Abstract excerpt

Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-analysis of...

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Identifiers

PMID: 27067015
DOI: 10.1038/mp.2016.49
PMCID: PMC4879189

Genes

CELF4
CRHR1
GRIK3
KLHL2
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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