Article
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
JAMA psychiatry - 1 Jul 2015
de Moor Marleen H M, van den Berg Stéphanie M, Verweij Karin J H, Krueger Robert F, Luciano Michelle, Arias Vasquez Alejandro, Matteson Lindsay K, Derringer Jaime, Esko Tõnu, Amin Najaf, Gordon Scott D, Hansell Narelle K, Hart Amy B, Seppälä Ilkka, Huffman Jennifer E, Konte Bettina, Lahti Jari, Lee Minyoung, Miller Mike, Nutile Teresa, Tanaka Toshiko, Teumer Alexander, Viktorin Alexander, Wedenoja Juho, Abecasis Goncalo R, Adkins Daniel E, Agrawal Arpana, Allik Jüri, Appel Katja, Bigdeli Timothy B, Busonero Fabio, Campbell Harry, Costa Paul T, Davey Smith George, Davies Gail, de Wit Harriet, Ding Jun, Engelhardt Barbara E, Eriksson Johan G, Fedko Iryna O, Ferrucci Luigi, Franke Barbara, Giegling Ina, Grucza Richard, Hartmann Annette M, Heath Andrew C, Heinonen Kati, Henders Anjali K, Homuth Georg, Hottenga Jouke-Jan, Iacono William G, Janzing Joost, Jokela Markus, Karlsson Robert, Kemp John P, Kirkpatrick Matthew G, Latvala Antti, Lehtimäki Terho, Liewald David C, Madden Pamela A F, Magri Chiara, Magnusson Patrik K E, Marten Jonathan, Maschio Andrea, Medland Sarah E, Mihailov Evelin, Milaneschi Yuri, Montgomery Grant W, Nauck Matthias, Ouwens Klaasjan G, Palotie Aarno, Pettersson Erik, Polasek Ozren, Qian Yong, Pulkki-Råback Laura, Raitakari Olli T, Realo Anu, Rose Richard J, Ruggiero Daniela, Schmidt Carsten O, Slutske Wendy S, Sorice Rossella, Starr John M, St Pourcain Beate, Sutin Angelina R, Timpson Nicholas J, Trochet Holly, Vermeulen Sita, Vuoksimaa Eero, Widen Elisabeth, Wouda Jasper, Wright Margaret J, Zgaga Lina, Porteous David, Minelli Alessandra, Palmer Abraham A, Rujescu Dan, Ciullo Marina, Hayward Caroline, Rudan Igor, Metspalu Andres, Kaprio Jaakko, Deary Ian J, Räikkönen Katri, Wilson James F, Keltikangas-Järvinen Liisa, Bierut Laura J, Hettema John M, Grabe Hans J, van Duijn Cornelia M, Evans David M, Schlessinger David, Pedersen Nancy L, Terracciano Antonio, McGue Matt, Penninx Brenda W J H, Martin Nicholas G, Boomsma Dorret I
Abstract excerpt
IMPORTANCE: Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63,000 participants (including MDD cases). OBJECTIVES: To identify genetic...