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Article

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.

Nature genetics - 1 Jan 2018

Luciano Michelle, Hagenaars Saskia P, Davies Gail, Hill W David, Clarke Toni-Kim, Shirali Masoud, Harris Sarah E, Marioni Riccardo E, Liewald David C, Fawns-Ritchie Chloe, Adams Mark J, Howard David M, Lewis Cathryn M, Gale Catharine R, McIntosh Andrew M, Deary Ian J

Abstract excerpt

Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) 1 ; heritability estimated from twin studies ranges from 30 to 50% 2 , and SNP-based heritability ranges from 6 to 15% 3-6 . Increased neuroticism is associated with poorer mental and physical health 7,8 , translating to high economic burden 9 . Genome-wide association studies (GWAS) of...

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Genome-Wide Association Study
Neuroticism
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29255261
DOI: 10.1038/s41588-017-0013-8
PMCID: PMC5985926

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