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Article

Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.

Biological psychiatry - 1 Feb 2023

Wendt Frank R, Pathak Gita A, Singh Kritika, Stein Murray B, Koenen Karestan C, Krystal John H, Gelernter Joel, Davis Lea K, Polimanti Renato

Abstract excerpt

BACKGROUND: The presentation, etiology, and relative risk of psychiatric disorders are strongly influenced by biological sex. Neuroticism is a transdiagnostic feature of psychiatric disorders displaying prominent sex differences. We performed genome-wide association studies of neuroticism separately in males and females to identify sex-specific genetic and transcriptomic profiles. METHODS: Neuroticism scores were...

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Identifiers

PMID: 36244801
DOI: 10.1016/j.biopsych.2022.07.019
PMCID: PMC10508260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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