Article
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
Nature genetics - 1 Jul 2018
Nagel Mats, Jansen Philip R, Stringer Sven, Watanabe Kyoko, de Leeuw Christiaan A, Bryois Julien, Savage Jeanne E, Hammerschlag Anke R, Skene Nathan G, Muñoz-Manchado Ana B, White Tonya, Tiemeier Henning, Linnarsson Sten, Hjerling-Leffler Jens, Polderman Tinca J C, Sullivan Patrick F, van der Sluis Sophie, Posthuma Danielle
Abstract excerpt
Neuroticism is an important risk factor for psychiatric traits, including depression1, anxiety2,3, and schizophrenia4-6. At the time of analysis, previous genome-wide association studies7-12 (GWAS) reported 16 genomic loci associated to neuroticism10-12. Here we conducted a large GWAS meta-analysis (n = 449,484) of neuroticism and identified 136 independent genome-wide significant loci (124 new at the time of...
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