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Article

Gene-based association analysis identifies 190 genes affecting neuroticism.

Scientific reports - 28 Jan 2021

Belonogova Nadezhda M, Zorkoltseva Irina V, Tsepilov Yakov A, Axenovich Tatiana I

Abstract excerpt

Neuroticism is a personality trait, which is an important risk factor for psychiatric disorders. Recent genome-wide studies reported about 600 genes potentially influencing neuroticism. Little is known about the mechanisms of their action. Here, we aimed to conduct a more detailed analysis of genes that can regulate the level of neuroticism. Using UK Biobank-based GWAS summary statistics, we performed a...

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Genome-Wide Association Study
Mental Disorders
Multifactorial Inheritance
Neuroticism
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33510330
DOI: 10.1038/s41598-021-82123-5
PMCID: PMC7844228

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