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Article

Repeat mediated excision of gene drive elements for restoring wild-type populations.

PLoS genetics - 1 Nov 2024

Chennuri Pratima R, Zapletal Josef, Monfardini Raquel D, Ndeffo-Mbah Martial Loth, Adelman Zach N, Myles Kevin M

Abstract excerpt

Here, we demonstrate that single strand annealing (SSA) can be co-opted for the precise autocatalytic excision of a drive element. We have termed this technology Repeat Mediated Excision of a Drive Element (ReMEDE). By engineering direct repeats flanking the drive allele and inducing a double-strand DNA break (DSB) at a second endonuclease target site within the allele, we increased the utilization of SSA repair....

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Identifiers

PMID: 39509462
DOI: 10.1371/journal.pgen.1011450
PMCID: PMC11584131

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