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Engineering a self-eliminating transgene in the yellow fever mosquito,Aedes aegypti

30 Mar 2022

Abstract excerpt

Abstract Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that is particularly relevant for highly invasive gene drive transgenes. Here, we lay the groundwork for a transgene removal system based on single-strand annealing (SSA), a eukaryotic DNA repair...

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PMID: 36713320
DOI: 10.1093/pnasnexus/pgac037

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