Article
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.
Nature communications - 3 Nov 2020
Adolfi Adriana, Gantz Valentino M, Jasinskiene Nijole, Lee Hsu-Feng, Hwang Kristy, Terradas Gerard, Bulger Emily A, Ramaiah Arunachalam, Bennett Jared B, Emerson J J, Marshall John M, Bier Ethan, James Anthony A
Abstract excerpt
Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification (replacement/alteration) approaches, which interfere with competence to transmit pathogens. Here, we...
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