Article
Genetic conversion of a split-drive into a full-drive element.
Nature communications - 12 Jan 2023
Terradas Gerard, Bennett Jared B, Li Zhiqian, Marshall John M, Bier Ethan
Abstract excerpt
The core components of CRISPR-based gene drives, Cas9 and guide RNA (gRNA), either can be linked within a self-contained single cassette (full gene-drive, fGD) or be provided in two separate elements (split gene-drive, sGD), the latter offering greater control options. We previously engineered split systems that could be converted genetically into autonomous full drives. Here, we examine such dual systems...
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